To understand fatty liver disease you need to understand normal liver function. We have characterized biochemical mechanisms in the liver and have deep expertise in bile acid homeostasis, transporter function, xenobiotic metabolism, and gene regulation including key the nuclear receptors: AhR, CAR, PXR, FXR, and LXR. Our in vitro hepatic models integrate key pathways and can predict the effect of your compound on the liver and as a potential therapy for liver disease.
Our model integrates all relevant hepatic interactions:
- Uptake: Hepatic uptake of bile acids and cholesterol
- Efflux: Biliary and basolateral clearance of bile acids and lipids
- Metabolism: Metabolic enzymes for elimination
- Regulation: Gene regulation of bile acid homeostasis