Hepatic Clearance

At Qualyst, we offer the only in vitro model that can quantitate hepatic uptake, intracellular concentration, basolateral and biliary efflux, and biliary clearance. The elimination route of parent compounds and their metabolites, whether basolateral or biliary, is critical to predicting the pharmacokinetics of a compound, its toxicity profile and systemic exposure of metabolites. Our novel “parallel design” method, using B-CLEAR® Technology with Transporter Certified™ hepatocytes, enables us to quantitate biliary efflux separately from basolateral efflux and provide an in vivo-relevant estimate of hepatic clearance.