Drug-Drug Interaction Studies
We use Transporter Certified™ human hepatocytes in sandwich culture for CYP450 enzyme induction assays. Our methodology ensures that hepatic uptake and efflux transporters are functioning in the model, and therefore intracellular concentrations (ICC) reflect in vivo physiologic conditions. Compared to conventional, transporter-deficient models we have demonstrated that our model has better in vitro-in vivo correlations and is superior at predicting clinical outcomes.
The ICC of a test article determines its induction potential. Transporter-deficient models can result in higher or lower ICC estimates than occur in vivo, causing a model to over or under-predict CYP enzyme induction potential and the risk of drug-drug interactions (DDIs).