Qualyst Transporter Solutions, LLC Awarded EPA Contract: Qualyst to investigate biliary clearance of chemicals using B-CLEAR® Technology
Durham, N.C. (August 14, 2017) – Qualyst Transporter Solutions, LLC (Qualyst) was awarded an US Environmental Protection Agency (EPA) contract to conduct an in vitro hepatic screen of biliary clearance, biliary transporter interaction, and intracellular concentration of selected chemicals including compounds used in crop protection products.
The study is being conducted as part of the EPA’s ToxCast™ Toxicity Forecaster. ToxCast generates data and predictive models on thousands of chemicals of interest to EPA. It is expected that data generated by Qualyst will help to refine computer models that link disruptions in cellular responses to an external dose.
“We are pleased to be working with colleagues at the EPA to evaluate the impact of exposure to representative chemicals”, said Dr. Chris Black, CEO at Qualyst. “We have demonstrated that our in vitro hepatic model, where key metabolic and regulatory pathways are integrated and functioning together, is effective in predicting adverse outcome pathways of compounds in the liver.”
Compounds that Qualyst will screen include herbicides, fungicides, insecticides, and other agricultural chemicals with significant market uptake in the United States.
About Qualyst Transporter Solutions, LLC
Qualyst Transporter Solutions, LLC (Qualyst) provides in vitro hepatic models to predict the effect of drugs and other compounds on the human liver. Qualyst’s in vitro models integrate hepatic uptake, metabolism, regulation, and efflux and demonstrate superior in vitro-in vivo correlation compared to conventional systems. Qualyst’s proprietary technology, products, and services are used by leading pharmaceutical, nutrition, cosmetics and consumer products, and chemical companies to provide clinically-relevant answers to liver-related questions, and to address regulatory concerns about their products.