What is B-CLEAR®?

B-CLEAR technology refers to a patented methodology that, when applied to properly functioning hepatocytes in culture, opens the bile pockets, analogous to bile canaliculi, allowing the measurement of material that has been transported from inside the cell. Measurement of biliary efflux allows us to evaluate biliary clearance and biliary transporter interactions, as well as perform cellular mass balance measurements. B-CLEAR technology platforms are patented in 45 countries.

Data from the B-CLEAR model has been used in a variety of ways including in the prediction of clinically relevant drug interactions and in regulatory submissions to the FDA in support of mechanisms of transporter interactions and hepatotoxicity.